Pep Guardiola will be without his highest goal scorer, Sergio Aguero following a ban by FA for a terrible challenge on David Luiz during a heated clash.
Sergio Kun Aguero
Manchester City striker Sergio Aguero has been banned for four matches after his second dismissal for violent conduct this season.
Aguero, 28, was sent off for a high and late challenge on Chelsea defender David Luiz in Saturday's 3-1 home loss.
The Argentina forward's previous dismissal was in August, when he received a retrospective red card for a challenge on West Ham's Winston Reid.
He will miss City's games against Leicester, Watford, Arsenal and Hull.
City's Fernandinho was also sent off after he clashed with Cesc Fabregas in the scuffle that followed Aguero's lunge, and the midfielder will serve a three-match ban.
The aftermath of the tackle
Several players from both sides ran to the scene of Aguero's foul and Chelsea midfielder Nathaniel Chalobah pushed Aguero to the ground.
As City striker Kelechi Iheanacho tried to confront Chalobah, Fabregas held him back from behind. Fernandinho appeared to then try to separate the Spaniard from his team-mate by dragging him away.
After Fabregas appeared to slap him, Fernandinho grabbed the Chelsea midfielder by the throat and continued to push him until he tumbled backwards over the advertising boards.